Disc1 Knockout Rat
This model contains a biallelic deletion within the Disc1 (disrupted in schizophrenia 1) gene, encoding the DISC1 protein. A translocation disrupting Disc1 was discovered to co-segregate with major psychiatric illness in a Scottish family. This model is useful in the study of schizophrenia.Disc1 Knockout Rat Characteristics: Disc1 is involved in neuronal growth and cortical development The protein also regulates the pro…
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This model contains a biallelic deletion within the Disc1 (disrupted in schizophrenia 1) gene, encoding the DISC1 protein.
A translocation disrupting Disc1 was discovered to co-segregate with major psychiatric illness in a Scottish family. This model is useful in the study of schizophrenia.
Disc1 Knockout Rat Characteristics:
- Disc1 is involved in neuronal growth and cortical development
- The protein also regulates the proliferation of embryonic and adult neuronal progenitor cells through the GSK3/β-catenin pathway
- Preliminary reports suggest impaired prepulse inhibition in Disc1 knockout rats
- Background Strain: Sprague-Dawley
Research Applications:
- Schizophrenia
- Bipolar disorder
- Neuronal growth and transport studies
