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DMH1
Activin/Nodal/TGFß pathway inhibitor; Inhibits ALK2
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DMH1 (dorsomorphin homolog 1) is a selective inhibitor of activin receptor-like kinase 2 (ALK2; IC₅₀ = 13 - 108 nM), a type I bone morphogenetic protein (BMP) receptor (Hao et al.; Mohedas et al.). DMH1 exhibits no detectable inhibition of ALK4, ALK5, AMPK, KDR (VEGFR2), or PDGFRβ, although it inhibits ALK1 and ALK3 at nanomolar concentrations (Hao et al.; Mohedas et al.).
DIFFERENTIATION
- Induces differentiation of mouse embryonic stem cells to cardiomyocyte progenitor cells (Ao et al.).
- Induces differentiation of human induced pluripotent stem cells to SOX1 and PAX6 expressing neural precursor cells (Neely et al.).
- Dorsalizes the embryonic axis without disrupting the angiogenic process in early zebrafish embryos (Hao et al. 2010).
CANCER RESEARCH
- Suppresses non-small cell lung cancer cell growth, migration and invasion in vitro, and attenuates xenografted lung tumor growth in vivo (Hao et al. 2014).
- Inhibits chemotherapeutic drug-induced autophagy response (Sheng et al.).