DMPK/ADME Services

Crown Bioscience stands at the forefront of drug discovery exploration, offering a suite of DMPK services that illuminate the path from early discovery to Investigational New Drug (IND) submission. Crown Bioscience's DMPK platform is a harmonious blend of in vitro and in vivo studies, meticulously designed to provide insights into the Absorption, Distribution, Metabolism, and Excretion (ADME) profiles of drug candidates. This integrated approach ensures that potential issues are identified and addressed early, streamlining the development process.

In Vitro ADME Services:

• Physicochemical Property Assessment: Evaluating solubility and stability to predict absorption and formulation strategies.
• Matrix Stability Studies: Analyzing compound stability in plasma, serum, whole blood, tissues, and buffers.
• Plasma Protein Binding: Determining the extent of drug binding to plasma proteins, influencing distribution and efficacy.
• Metabolic Stability: Utilizing liver microsomes, S9 fractions, and hepatocytes to assess metabolic pathways.
• Caco-2 Permeability and Transporter Studies: Predicting intestinal absorption and identifying potential drug-drug interactions.
• Red Blood Cell Distribution: Understanding compound partitioning between plasma and red blood cells.