Drug Discovery Services

Positive hits from your high-throughput screen are promising, but it’s not worth proceeding down the drug development pathway without evaluating your compound’s characteristics first. To ensure the fastest and least expensive journey of your compound to preclinical nomination, consult with Charles River drug discovery chemists and biologists early. Their integrated approach to designing, synthesizing, and optimizing compounds efficiently advances your therapeutic drug.

Eliminate complicated logistics, increased administrative costs, and cycle time slippage by contracting with a preclinical drug discovery CRO that manages your project from drug target discovery to hit identification, hit-to-lead, and lead optimization. Charles River offers these services:

Chemistry:

• Artificial Intelligence for Drug Discovery
• Isotopic Labeling Services
• Medicinal Chemistry
• Metabolite Synthesis Services
• Computer-Aided Drug Design
• Synthetic Chemistry
• Analytical Chemistry
• Process & Scale-up Chemistry
• Physical Characterization & Pharmaceutical Sciences

Biology:

• Screening & Profiling Assays
• In Vitro Assay Development Services
• High-Throughput Screening (HTS)
• Screening Libraries
• Structural Biology
• High Content Imaging
• Capture Compound^® Mass Spectrometry

DMPK ADME Studies:

• High-Throughput ADME (HT-ADME)
• In Vitro ADME
• SOLVO Drug Transporter Assays
• In Vivo ADME
• Pharmacokinetic Screening
• Pharmacokinetics / Toxicokinetics
• Tissue Distribution / QWBA
• Metabolite Identification

Pharmacology Studies:

• Cardiovascular/Metabolic Disease Studies
• Infectious Disease Studies
• Inflammation & Autoimmune Disease Studies
• Musculoskeletal Disease Studies
• Neuroscience Studies
• Ocular Disease Studies
• Oncology & Immuno-Oncology Studies
• Rare Disease Studies
• Respiratory Disease Studies