(-)-Epigallocatechin Gallate
Antioxidant and epigenetic modifier; Inhibits DNA methyltransferases (DNMTs)
(-)-Epigallocatechin Gallate
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(-)-Epigallocatechin Gallate is the most abundant polyphenol catechin antioxidant present in green tea (Frémont et al.; Johnson & Maddipati; Miller & Rice-Evans) and is known to inhibit DNA methyltransferases (DNMTs; IC₅₀ = 0.21 - 0.47 μM; Lee et al.). (-)-Epigallocatechin Gallate also inhibits the formation of oxidized low-density lipoproteins (Yoshida et al.), which have a pathological role in cardiovascular diseases and atherosclerosis (Itabe et al.). (-)-Epigallocatechin Gallate has also been shown to inhibit peroxynitrite-mediated formation of 8-oxodeoxyguanosine and 3-nitrotyrosine (Fiala et al.).
DIFFERENTIATION
- Inhibits bone resorption by inducing cell death of osteoclast-like multinucleated cells but not osteoblastic cells (Nakagawa et al.)
CANCER RESEARCH
- Inhibits growth and induces apoptosis in human pancreatic cancer cells in mouse xenograft model (Shankar et al., Du et al.)
- Causes cell cycle deregulation and apoptosis in human epidermoid cancer cell line, possibly via inhibition of NF-κB (Ahmad et al.).
