FabULOUS® (SpeB)
FabULOUS (SpeB) is a recombinantly produced cysteine protease that under reduced conditions digests in the hinge region of antibodies from many species and subclasses, including human, mouse, rat and goat.
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Unique enzyme to obtain intact Fc fragments
Generating intact Fc fragments
FabULOUS is a protease which cuts in the hinge region of antibodies generating two Fab fragments and a intact Fc fragment (linked by disulfide bridges). Used in the lab e.g. for the evaluation of glyco pairing.
Review Date: 27 Apr 2018 | Genovis
FabULOUS (SpeB) is a recombinantly produced cysteine protease that under reduced conditions digests in the hinge region of antibodies from many species and subclasses, including human, mouse, rat and goat. FabULOUS is available in two product formats: as a lyophilized powder (FabULOUS Enzyme) and as a lyophilized powder in a kit together with affinity spin columns (FabULOUS Fab kit), for easy preparation and purification of Fab fragments from mouse IgG.
FabULOUS Primary Digestion Site:
- Human IgG1 ..KTHT / CPPCPAPEL..
- Mouse IgG1 ..KPCIC / TVPEVS..
The molecular weight of FabULOUS is 28 724 Da and the enzyme contains a His-tag.
