Fasudil

Fasudil (also known as HA-1077) is a potent inhibitor of Rho-associated coiled-coil containing protein kinase 2 (ROCK2; IC₅₀ = 1.9 µM). Additionally, it inhibits protein kinase C-related kinase 2 (PRK2), mitogen- and stress-activated protein kinase (MSK1), and mitogen-activated protein kinase-activated protein kinase 1b (MAPKAP-K1b) with IC₅₀ values of 4, 5, and 15 µM, respectively (Davies et al.). This product is supplied as the dihydrochloride salt of the molecule.

DIFFERENTIATION

• Suppresses proliferation and collagen production but also increases collagenase activity of hepatic stellate cells (Fukushima et al..
• Inhibits endothelial cell migration, viability, and tube formation in vitro in HUVECs (Yin et al.)
• Improves adipocyte differentiation, preventing development of diabetes and nephropathy in insulin-resistant diabetic rats (Kikuchi et al.).

DISEASE MODELING

• Reduces pulmonary arterial hypertension in rats (Oka et al.).
• Enhances neurological recovery after traumatic spinal cord injury (Hara et al.).
• Inhibits corneal neovascularization after alkali burns and promotes the healing of corneal epithelial defects in mice (Zeng et al.).