Products & ReviewLife Sciences
Fluprostenol
Prostanoid pathway activator; Activates prostaglandin F2a receptor
Fluprostenol
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Fluprostenol is a metabolically stable analog of prostaglandin F2α (PGF2α) with potent PGF2α receptor agonist activity (Abramovitz et al.). Fluprostenol competitively binds to human and rat PGF2α receptors with IC₅₀ values of 3.5 and 7.5 nM, respectively (Abramovitz et al.; Lake et al.).
DIFFERENTIATION
- Inhibits adipose differentiation of newborn rat adipocyte precursors in primary culture (Serrero & Lepak)
DISEASE MODELING
- Inhibits endothelin""“induced contraction of the trabecular meshwork in bovine ocular tissue in vitro, a model of intraocular pressure in glaucoma (Thieme et al.).
