Products & ReviewLife Sciences
GANT 58
Hedgehog pathway inhibitor; Inhibits GLI1
GANT 58
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GANT 58 inhibits the Hedgehog signaling pathway downstream of Smoothened and Suppressor of Fused (SUFU) leading to GLI1 nuclear accumulation (Joo et al.; Stanton & Peng). GANT 58 demonstrates antiproliferative and antitumor activity in vivo (Beauchamp et al.; Joo et al.).
CANCER RESEARCH
- li>Reduces anchorage-independent growth in Ewing Sarcoma cells (Beauchamp et al.; Joo et al.).
- Inhibits prostate cancer tumor growth (Lauth et al.).
- Causes cell cycle arrest and apoptosis in acute leukemia T cells (Hou et al.).
