Products & ReviewLife Sciences
Garcinol
Epigenetic modifier; Inhibits histone acetyltransferases (HATs) p300 and pCAF
Garcinol
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Garcinol is an inhibitor of histone acetyltransferases (HATs) p300 and pCAF (IC₅₀ = 7 and 5 μM, respectively) (Balasubramanyam et al.). It also inhibits the HAT GCN5 in Cryptococcus neoformans, inducing temperature sensitivity and impairing growth (O'Meara et al.).
MAINTENANCE AND SELF-RENEWAL
- Promotes ex vivo expansion of human hematopoietic stem cells (Nishino et al.).
DIFFERENTIATION
- Promotes neurogenesis in rat cortical progenitor cells (Weng et al.).
CANCER
- Induces apoptosis in several types of cancer cells and has anti-inflammatory actions (Koeberle et al.; Prasad et al.).
