Genistein
NF-kB, AMPK, and tyrosine kinase pathway inhibitor; Inhibits tyrosine kinase and topoisomerase II and activates PPAR?
Genistein
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Genistein is a phytoestrogen that exhibits a wide range of biological effects. It acts by competing for the ATP-binding site of tyrosine kinases but does not inhibit the activity of serine- and threonine-specific kinases such as cAMP-dependent protein kinase, protein kinase C, and phosphorylase kinase (Akiyama et al.). Genistein binds to and activates peroxisome proliferator-activated receptor-gamma (PPARγ) and estrogen receptors, leading to a decrease in osteogenesis and an increase in adipogenesis (Dang et al.). Genistein also binds and activates the seven-transmembrane estrogen receptor GPR30 to activate alternative estrogen signaling pathways (Thomas & Dong).
DIFFERENTIATION
- Inhibits adipocyte differentiation in 3T3-L1 cell culture (Hwang et al.).
- Control of osteoblast and adipocyte cell fates in mouse bone marrow cells (Dang et al.).
CANCER RESEARCH
- Inhibits growth of leukemia, lymphoma, neuroblastoma, gastric, breast, and prostate cancer cells (Sarkar & Li).
