Genomics and Transcriptomics Services
Explore your translational research with Crown Bioscience’s comprehensive genomics services—offering PCR/qPCR, next-generation sequencing, and advanced bioinformatics to deliver high-quality, reproducible data for biomarker discovery and drug development.
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Comprehensive Genomics Services for Translational Research
In the rapidly evolving field of biomedical research, genomic analysis has become indispensable for understanding disease mechanisms, identifying biomarkers, and developing targeted therapies. Crown Bioscience offers a suite of genomics services designed to provide high-quality, reproducible data to support your research objectives.
Core Genomics Services:
Standard Genomics Services: Utilizing automated workflows, Crown Bioscience provides PCR, qPCR, and Sanger sequencing assays. These services ensure efficient and cost-effective analyses with high reproducibility, essential for reliable results in various research applications.
Next-Generation Sequencing (NGS): Employing both second- and third-generation sequencing platforms, including Illumina's NovaSeq 6000 and PacBio's Sequel II, Crown Bioscience delivers high-throughput sequencing solutions. These platforms enable comprehensive genomic analyses, such as whole-genome sequencing (WGS), whole-exome sequencing (WES), and RNA-Seq, facilitating in-depth exploration of genetic variations and gene expression profiles.
Optical Genome Mapping: Using Bionano's Saphyr system, Crown Bioscience offers optical genome mapping services to detect large structural variants and genome rearrangements with high accuracy, complementing sequencing data for a more complete genomic landscape.
Single-Cell Gene Expression Analysis: Implementing the 10x Genomics Chromium platform, Crown Bioscience provides single-cell RNA sequencing services. This technology allows for the investigation of gene expression at the individual cell level, uncovering cellular heterogeneity and enabling the identification of rare cell populations within complex tissues.
Specialized Services:
Cell Line Authentication with Deep Sequencing: Crown Bioscience offers a proprietary service for authenticating cell lines using deep sequencing techniques. This ensures the validity and reliability of cell-based experiments by confirming the identity and purity of cell lines used in research.
Mouse I/O RNA-Seq Panel: A specialized RNA-Seq panel focused on murine immuno-oncology, this service enables researchers to profile immune-related gene expression in mouse models, aiding in the understanding of tumor-immune interactions and the evaluation of immunotherapies.
Data Analysis and Bioinformatics:
Crown Bioscience complements its laboratory services with robust bioinformatics support. Their data analysis services include quality control, alignment, variant calling, and functional annotation, transforming raw sequencing data into meaningful biological insights. This comprehensive approach ensures that researchers can interpret their data accurately and make informed decisions in their studies.
Applications in Research:
- Biomarker Discovery and Validation: Identify genetic markers associated with disease states or therapeutic responses.
- Mechanism of Action Studies: Elucidate how drugs interact with their targets and affect cellular pathways.
- Drug Development Support: Assess drug efficacy and toxicity through comprehensive genomic profiling.
crownbio.com - Disease Mechanism Research: Investigate the genomic alterations associated with various diseases to uncover underlying mechanisms.
