Products & ReviewLife Sciences
GSA 10
Hedgehog pathway activator; Activates Smoothened (SMO)
GSA 10
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GSA 10 is an agonist of Smoothened (SMO), a cell surface receptor and mediator of the hedgehog signaling pathway. It is a quinolinecarboxamide derivative that binds in a distinct binding pocket from cyclopamine. GSA10 is active at an EC₅₀ of 1.2 μM in an alkaline phosphatase-based mouse mesenchymal cell line (C3H10T1/2) differentiation assay (Gorojankina et al.).
DIFFERENTIATION
- Promotes differentiation of multipotent mesenchymal progenitor cells into osteoblasts (Gorojankina et al.).
