Hypersil Duet C18/SCX Columns
o Separate hydrophobic and ionic compounds in a single runo Select from two mixed mode phases, using either cation or anion exchange combined with C18o Retention of compounds is optimized using mobile phase pH, ionic strength and percent organic Product detail: Hypersil Duet columns are an ideal choice for unknown compounds and metabolism studies, as they can separate hydrophobic and ionic compounds in a single analysis…
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o Separate hydrophobic and ionic compounds in a single run
o Select from two mixed mode phases, using either cation or anion exchange combined with C18
o Retention of compounds is optimized using mobile phase pH, ionic strength and percent organic
Product detail:
Hypersil Duet columns are an ideal choice for unknown compounds and metabolism studies, as they can separate hydrophobic and ionic compounds in a single analysis run. Retention of ionizable species is manipulated by adjustment of the mobile phase pH, and retention of hydrophobic compounds is control by a solvent gradient.
Duet SCX/C18 is a mixed-mode phase with 50% hydrophobic stationary phase (C18) and 50% strong ion cation exchanger (sulfonic acid). This stationary phase makes expensive and time-consuming procedures such as column switching, using ion pair reagents or using columns in series redundant.
The main application areas of Hypersil Duet lie in metabolism studies, where the main component has strong hydrophobic character but the metabolites contain ionic groups.
Other column dimensions and hardware designs are available. Please contact us for more information if you do not see the exact column that you are interested in.
