Products & ReviewLife Sciences
IDE2
Activin/BMP/TGF-ß pathway activator
IDE2
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Inducer of definitive endoderm 2 (IDE2) induces differentiation of mouse or human pluripotent stem cells (PSCs) by activating SMAD2 phosphorylation and NODAL expression (Borowiak et al.). At EC₅₀ = 223nM, SOX17 expression was induced in mouse ES cells.
DIFFERENTIATION
- Induces definitive endoderm from mouse or human ES cells in the absence of Activin A, NODAL, or feeder cells (Borowiak et al.).
