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Impurity Profiling Suite

Predict Genotoxic & Carcinogenic Endpoints to Meet ICH M7 Guidelines

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Advanced Chemistry Development, Inc.,  (ACD/Labs)

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ACD/Impurity Profiling Suite predicts a variety of toxicological endpoints to help you assess the genotoxic and carcinogenic potential of impurities and degradants.

  • Determine the ICH M7 classification for impurities and degradants
  • Predict 21 toxicological endpoints from structure; for mechanisms of hazardous activity including:
    • Mutagenicity (AMES test and other procaryote and eucaryote test systems)
    • Clastogenicity
    • Other DNA damage
    • Carcinogenicity
    • Endocrine disruption mechanisms
  • Identify potentially hazardous structural fragments responsible for carcinogenic and genotoxic activity
  • Gain insight into the possible mechanisms of toxic effects

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