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(-)-Indolactam V
Protein kinase C (PKC) activator
(-)-Indolactam V
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(-)-Indolactam V is an indole alkaloid compound that activates protein kinase C (PKC). It binds to the α, β, γ, δ, ε, and η isozymes of PKC with Ki values of 11, 6, 19, 8, 22, and 16 nM respectively. (Kazanietz et al., Masuda et al.)
DIFFERENTIATION
- Promotes differentiation to human and mouse pancreatic precursors from pluripotent stem cell-derived definitive endoderm (Borowiak et al., Chen et al., Thatava et al.).
