IQFISH Panel for Lung Cancer
Fastest time to result
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Agilent IQFISH product is excellent
cancer molecular pathology
Easy to use with good quality, yes, I would recommend
Review Date: 3 Aug 2017 | Agilent Technologies
The IQFISH panel for lung cancer is a set of oligonucleotide-based FISH probes, premixed with IQFISH Buffer, for the detection of rearrangements involving the ALK, ROS1 and RET genes, and the detection of MET gene amplification by fluorescence in situ hybridization (FISH). These probes are to be used on lung paraffin-embedded tissue sections.
Non-Small Cell Lung Cancer (NSCLC) may involce genetic aberrations that can be used to direct therapy. For example, a fusion of ALK with EML4 occurs in about 5% of cancers and is linked to strong patient response to treatment with Crizotinib. Fusions of ROS1 and RET or amplification of MET are also observed with potentioal treatment indication. Identification of these abnormalities is often done using FISH.
This panel of IQFISH Probes combines new generations of FISH technologies-oligonucleotide-based FISH in a ready-to-use formulation of IQ Hybridization Buffer. The result is higher signal-to-noise ratios in a less than 4-hour turnaround time, reducing the costs associated with labor and assays failures.
Less Anaylsis Time
- Reduce background with probes free of repetitive DNA
- Eliminate Cot-l DNA which can suppress signal
- Get tighter signal co-localization for better visualization
Less Processing Time
- Hybridize probe with specimen for only 90-minutes without loss of signal
- Achieve up to 25% greater operational efficiency
Lower Assay Repeat Time
- Achieve more consistent results across a range of tissues
- Save on reagent and labor costs by repeating assays less often
