Products & ReviewLife Sciences
IWP-3
WNT pathway inhibitor; Inhibits Porcupine
IWP-3
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Inhibitor of WNT Production-3 (IWP-3) inhibits WNT signaling by inactivating Porcupine, a membrane-bound O-acyltransferase responsible for palmitoylating WNT proteins, which is essential for WNT signaling ability and secretion (Chen et al.). IWP-3 impairs WNT pathway activity in vitro with an IC₅₀ value of 40 nM (Chen et al.).
DIFFERENTIATION
- Promotes cardiomyocyte differentiation from human embryonic stem cells that have been induced to mesoderm by addition of BMP4 and Activin A (Willems et al.).
