Products & ReviewLife Sciences
IWR-1-endo
WNT pathway inhibitor; AXIN2 stabilizer
IWR-1-endo
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IWR-1-endo potently inhibits WNT signaling by blocking a cell-based WNT/β-catenin pathway reporter response with an IC₅₀ value of 180 nM (Chen et al.). It inhibits WNT-induced accumulation of β-catenin, through stabilization of the destruction complex member AXIN2 (Chen et al.).
MAINTENANCE AND SELF-RENEWAL
- Promotes self-renewal and maintains pluripotency of human embryonic stem cells and mouse Epi-stem cells when used in combination with CHIR99021 (Kim et al.).
DIFFERENTIATION
- Promotes differentiation of cardiomyocytes from human pluripotent stem cells (PSCs) that have been induced to mesoderm by addition of Activin A and/or BMP4 (Ren et al.; Willems et al.)
- Induces the differentiation of human PSC-derived alveolar epithelial type II (AETII) to AETI cells (Ghaedi et al.).
