Ldlr Knockout Rat
The Low-Density Lipoprotein (LDL) receptor is directly involved in the development of atherosclerosis, due to accumulation of LDL cholesterol in the blood. Ldlr (-/-) rats show elevated serum cholesterol levels. Ldlr Knockout Rat Characteristics: This model possesses a 337 bp deletion and 4 bp insertion within Exon 4 on chromosome 8 Homozygous knockout rats display loss of LDLR protein via Western blot Homozygous knoc…
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The Low-Density Lipoprotein (LDL) receptor is directly involved in the development of atherosclerosis, due to accumulation of LDL cholesterol in the blood. Ldlr (-/-) rats show elevated serum cholesterol levels.
Ldlr Knockout Rat Characteristics:
- This model possesses a 337 bp deletion and 4 bp insertion within Exon 4 on chromosome 8
- Homozygous knockout rats display loss of LDLR protein via Western blot
- Homozygous knockout rats have increased body weight as compared to wild type
- Homozygous knockout rats show significantly elevated serum cholesterol levels
- Background Strain: Sprague-Dawley
Research Applications:
- Atherogenesis
- Atherosclerosis
- Hypertension
- Insulin resistance
- Lipoprotein/Cholesterol transportation
- Metabolism (Triglyceride/Cholesterol)
- Obesity
- Type II diabetes
