Products & ReviewLab Automation
Lead Discovery Services
BellBrook LabsAvailable: Worldwide
BellBrook Labs Lead Discovery Services
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We will work closely with you to define the specific parameters that are important for your lead discovery program and implement the most efficient and cost effective assays and/or kinetic analyses.
Lead Discovery Services Include:
- Inhibitor Screening – to identify or confirm activity with target
- Inhibitor Potency Profiling – dose response with target and/or related proteins
- Residence Time Measurements – determination of koff using ‘jump dilution’ enzymatic assay method
- Mechanism of Action Studies – kinetic analysis to define mode of inhibition
- Inhibitor Selectivity Profiling
Example Targets:
- Protein Kinases
- Lipid Kinases
- Carbohydrate Kinases
- ATPases
- Methyltransferases
- Acetyltransferases
- HDACs
- GTPases, GAPs, GEFs
- Phosphodiesterases
- Helicases
- Ligases/Synthetases
- Glycosyltransferases
