Products & ReviewDrug Discovery & Development
Lead Discovery Services
BellBrook LabsAvailable: Worldwide
BellBrook Labs’ Lead Discovery Services deliver expert support for hit-to-lead efforts. From inhibitor screening and potency profiling to residence-time, mechanism-of-action, and selectivity studies, their team tailors efficient enzymatic assays to your program—accelerating lead advancement with precision and flexibility.
Request Pricing
Receive your quote directly from the manufacturer.
We will work closely with you to define the specific parameters that are important for your lead discovery program and implement the most efficient and cost effective assays and/or kinetic analyses.
Lead Discovery Services Include:
- Inhibitor Screening - to identify or confirm activity with target
- Inhibitor Potency Profiling - dose response with target and/or related proteins
- Residence Time Measurements - determination of koff using €˜jump dilution€™ enzymatic assay method
- Mechanism of Action Studies - kinetic analysis to define mode of inhibition
- Inhibitor Selectivity Profiling
Example Targets:
- Protein Kinases
- Lipid Kinases
- Carbohydrate Kinases
- ATPases
- Helicases
- Methyltransferases
- Situins
- cGAS
- OAS
- GTPases, GAPs, GEFs
- CD38, CD39, CD73
- Phosphodiesterases
- Ligases/Synthetases
- Glycosyltransferases
