Products & Review
Locked Nucleic Acid probes
LGC Biosearch TechnologiesAvailable: Worldwide
Improve assay sensitivity and specificity with Locked Nucleic Acid oligonucleotides (LNA oligos). LNAs are modified RNA bases in which the ribose is “locked” with a methylene bridge, connecting the 2' oxygen atom to the 4' carbon atom, fixing it in the C3'-endo conformation.
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LNAs enable a shorter probe, which supports assay design for:
- Improved assay sensitivity
- Higher quenching efficiency (lower background)
- Greater signal-to-noise ratio
- Increased hybrization specificity
- Targeting A-T rich sequences
- Better mismatch discrimination in SNP genotyping assays
