MAGic™Accio System Process

Magnetic separators

MAGic bioprocessing provides magnetic separators (MAGic™Accio) that are optimized for easy and efficient capture of the magnetic resin from crude sample mixtures. The standard units are designed for durability with a lacquered plastic shell and nickel plated neodymium magnets placed safely inside. They fit standard test tubes and are available in sizes from 1 ml to liters. The larger custom units are proprietary designed magnetic systems (MAGic™Accio Process) made for efficient capture of 1-40 liters of magnetic beads from infinite volumes of complex feedstocks.

The MAGic™Accio series of laboratory magnetic separators have been optimized for use with MAGic™Beads and are ideal for most bioseparation applications. The LAB and PILOT units are designed for durability with a lacquered plastic shell and nickel-plated neodymium magnets placed safely inside. The separators fit standard test tubes and are available in sizes from 1 ml to 2,000 ml. The combination of MAGic™Beads and MAGic™Accio is a simple biomagnetic separation platform that requires no special training to use. The separators require very little maintenance, and several batches can be processed in parallel using the same unit, making the running costs very low. The larger custom units are proprietary designed magnetic separators (MAGic™Accio PROCESS) made for efficient capture of 1-40 liters of magnetic beads from infinite volumes of complex feedstocks.

During the production phase of biopharmaceuticals, large-scale recovery of the product from an unclarified cell-culture is performed in a one step clarification and purification by using the propietary designed MAGic™Accio PROCESS units together with our MAGic™Beads. The magnetic filter separators are capable to capture up to 40 liters of MAGic™Beads at high flow rates making them suitable to process up to kilo grams of proteins or antibodies per purification cycle.

• Process scale recovery of biologics
• High flow rates, 100-800 liter/h
• Pharmaceutical standard
• No column-clogging issues
• Automated
• 24/7 operation
• Captures 1-40 liters of MAGic™Beads per cycle
• Process 10-4,000 liters of culture volumes
• Recover kgs of mAbs per cycle

By utilizing the magnetic-based capture approach, the biopharmaceutical can be recovered directly from the cell-containing culture with the same or better quality as for a conventional 2-step clarification and purification mode using depth filters and column chromatography.