Parallel artificial membrane permeability assay (PAMPA) kits
Pion’s PAMPA high-throughput permeability assay uses a range of membranes to mimic physiologic conditions. It allows you to evaluate the passive permeability of API’s as well as the absorption potential of simple or complex formulations using robust models and protocols in a 96-well format.
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Benefits:
- Evaluate the passive permeability of API's as well as the absorption potential of simple or complex formulations.
- Classification of API’s can be performed on BBB lipid for blood-brain barrier permeability in the CNS classification system
- Permeability classification of API’s can be performed on GIT lipid to support the Biopharmaceutical Classification System (BCS) ranking
Bio-Mimetic Artificial Membrane Permeation Through:
Gastro Intestinal Tract (GIT)
GIT PAMPA vs. Human Jejunal Permeability
The GIT PAMPA (Double-Sink™) model data was initially developed against eight compounds evaluated at the University of Uppsala with human subjects. Since that time, additional data have been added, providing increased confidence in the model.
Blood Brain Barrier (BBB)
BBB PAMPA vs. Rodent Brain Perfusion
Nearly 40 CNS compounds were used for building the BBB PAMPA model.
The developed model can predict rodent brain perfusion uptake rate better than most more expensive cell-based assays in the market.
