Products & ReviewDrug discovery > Pre-Clinical Development
Patient-Derived Xenograft Models
PDX Models Empower your research with models that reflect today’s patients and treatments.
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Purpose: Clinically aligned pretreated PDX models are designed to help to develop innovative therapies for patients with high unmet needs. These models come from individuals previously treated with today’s most relevant regimens,such as KRAS inhibitors and immune checkpoint inhibitors,and often represent advanced metastatic disease.
Features or Benefits:
- 1000+ PDX models across 15+ cancer types
- Exposure to up to 5+ lines of therapy, including ICI, EGFRi, PARPi, CDK4/6i, KRASi, BTKi
- 45+ metastatic models from sites like liver, pleural fluid, lymph nodes
- Models kept in a “warm” state, no tissue revival required
Applications:
- Evaluate drug response in multi-treated, resistant, or metastatic cancers
- Model current clinical scenarios using biopsy-derived tumor tissue
- Screen and stratify candidates via mouse clinical trials and PDX organoids (PDXO)
- Advance immuno-oncology, biomarker discovery, and mechanism-of-action studies
