PhysioMimix® Bioavailability assay kit: Human 18
Fast-track your route to a modernized workflow with the only in vitro bioavailability assessment tool on the market
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The PhysioMimix Bioavailability assay kit: Human 18 contains everything you need to recreate our human in vitro Gut/Liver-on-a-chip model and Bioavailability assay in your laboratory.
The Bioavailability assay kit: Human 18 bridges the gap between in vitro and in vivo studies to reduce the risk calculus by enhancing your ability to profile human oral bioavailability ahead of in vivo animal and first-in-human trials.
The Bioavailability assay kit: Human 18 supports:
- The rapid adoption of Organ-on-a-chip technology by scientists of all experience levels
- Instant access to validated tissue models and protocols, developed and refined through years of industry collaboration
- Prediction of human-relevant ADME parameters by combining data generated from the assay kit with in silico modeling
- Ability to simulate oral and IV drug dosing in a single experiment
Features of the Bioavailability assay kit: Human 18
Use the assay kit to avoid unexpected results in the clinic by removing the limitations of traditional approaches that lead to incorrect estimations of ADME parameters.
- Modernize your workflow: Eliminate the need for model/assay development and validation with our all-in-one kit
- Assay kit output: gut and liver ADME estimations, plus oral bioavailability profiling via a fluidically linked multi-organ system
- Enhanced Study Design: Use the 18-replicate kit to explore and adapt parameters before in vivo animal studies, reducing the number of animals required.
- Unique Insights: Complement in vivo studies with human in vitro data to flag potential interspecies differences and reduce reliance on animal models.
- Validated primary human cells: Recapitulate the microarchitechture of the liver and human intestine.
- Proprietary media: Co-culture validated primary cells (for individual and combined Gut/Liver culture) up to 72 hours.
- Key metabolic enzyme expression: In both gut and liver, including CYP3A, CYP2C.
* You may require a license to store human cells in your geographic location.
