Pink1 (Park6) Knockout Rat
Developed in collaboration with The Michael J. Fox Foundation, this model contains a deletion of the Pink1 (PTEN-induced putative kinase 1) gene, encoding for a serine/threonine protein kinase. Mutations in Pink1 are implicated in early-onset Parkinson’s disease. Pink1 knockout rats show both motor impairments and dopaminergic cell loss, making this a useful model of Parkinson’s disease.Pink1 (Park6) Knockout Rat Characterist…
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Developed in collaboration with The Michael J. Fox Foundation, this model contains a deletion of the Pink1 (PTEN-induced putative kinase 1) gene, encoding for a serine/threonine protein kinase.
Mutations in Pink1 are implicated in early-onset Parkinson’s disease. Pink1 knockout rats show both motor impairments and dopaminergic cell loss, making this a useful model of Parkinson’s disease.
Pink1 (Park6) Knockout Rat Characteristics:
- Homozygous knockout rats exhibit complete loss of target protein
- Approximately 30% of Pink1 knockout rats display a hindlimb-dragging phenotype at 5 months of age
- Pink1 knockout rats show increased hindlimb fatigue at 7 weeks of age
- Pink1 knockout rats show increased number of hindlimb foot slips at 5 and 9 weeks of age as assessed by tapered balance beam
- Preliminary reports have suggested Pink1 knockout rats show a ~50% reduction in dopaminergic neurons in the substantia nigra at 8 months of age
- Background Strain: Long Evans Hooded
Research Applications:
- Parkinson's disease
- Stress-induced neurological dysfunction
