PRAME (EP461) Rabbit Monoclonal Primary Antibody

PRAME (PReferentially-expressed Antigen in MElanoma) is a gene encoded on the 22q11-22 chromosomal sequence and encodes a 509 amino acid residue protein. PRAME is a melanoma antigen that is preferentially expressed in tumors and is recognized by cytotoxic T lymphocytes. PRAME can be used to distinguish between malignant melanoma cells and nevus cells, and therefore may be useful for diagnostic purposes to support a suspected case of melanoma. PRAME is considered a cancer-testis antigen (CTA)5 and is not strongly expressed in most other normal tissues. PRAME is positively expressed in about half of uveal melanomas, and the majority of mucosal melanomas.

• Reactivity: paraffin
• Control: Melanoma (Nuclear)
• Dilution Range: 1:25-1:50 *