Rag1 Knockout Rat
In vivo model for xenograft and Immunology studies. Recombination Activation Genes (Rag) encode enzymes that play an important role in the rearrangement and recombination of the genes of immunoglobulin and T cell receptor molecules during the process of V(D)J recombination. Rag1 knockout rats lack mature B and T lymphocytes.Rag1 Knockout Rat Characteristics: 29 bp deletion within Exon 2 on chromosome 3 Homozygous Rag1 k…
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In vivo model for xenograft and Immunology studies.
Recombination Activation Genes (Rag) encode enzymes that play an important role in the rearrangement and recombination of the genes of immunoglobulin and T cell receptor molecules during the process of V(D)J recombination. Rag1 knockout rats lack mature B and T lymphocytes.
Rag1 Knockout Rat Characteristics:
- 29 bp deletion within Exon 2 on chromosome 3
- Homozygous Rag1 knockout rats display loss of RAG1 protein via Western blot
- Homozygous Rag1 knockout rats show loss of B and T cells by FACS analysis
- Background Strain: Sprague-Dawley
Research Applications:
- Xenograft
- Cancer metastasis
- Vaccine development
- Inflammation/Autoimmune disorders
- Thrombosis/Cardiac fibrosis
- Vascular defects
