REBEL
At-line cell culture media analysis. Results on 30+ components in under 10 minutes. When and where is your call. With the REBEL, now is always on the table.
Analyze spent media samples
The Rebel instrument by 908Devices is a wonderful instrument. The instrument functions as a mini mass spectrometer and can analyze amino acids, vitamins, and metabolites in spent media samples. This can be done in a matter of minutes per sample and only needs a starting spent media sample in the uL range (I typically only need about 50 uL per sample). Each chip can run 200 samples but that includes any duplicates/triplicates. If you are running all 200 samples it usually only take 15-24 hours to run them all depending if all. Their support team is great at anything you need and also helps with training and data processing. If there is a chip failure they will help asses the possible cause and will replace your chip when you send them the failed one. Prep time is minimal and only takes the time to filter the first diluted sample and then do any serial dilutions depending how many dilutions you plan to run. The instrument does the rest of the heavy lifting and time, where the user just has to wait for it to be done. They also have a range finding capability to see what dilution factor(s) would be best for your sample. If doing several samples from a bioreactor run or production model just be aware the the later days in the run will generally have less from consumption and a lower dilution factor may be needed. This instrument is a time saver over traditional spent media analysis methods and also can save on time and money if you are having to send your samples out for further analysis.
Review Date: 26 Sept 2022 | 908 Devices
The REBEL lets you run cell culture media analysis when and where you want it. Whether you are a process development scientist, an upstream process engineer, or a cell culture media development group, formulating chemically-defined blends, REBEL eliminates data analysis bottlenecks and accelerates biopharmaceutical process development. Challenge the status quo of sending media samples to a lab for analysis and waiting weeks for results, YOU run the REBEL alongside your bioreactors. The core lab doesn’t have to lift a finger and in minutes you’ll get a full report on concentrations of amino acids, dipeptides, water soluble vitamins and amines in your sample. Combine that with your other standard biochemical markers and make decisions in a snap. You’ll cut weeks off your process development time, if not more. To use the REBEL, simply pull a bioreactor sample, spin it down, and dilute. Load it in and hit start. Run samples solo or in 96-well plates if you’re a real go-getter. There’s no futzing around with settings or analysis. The REBEL already knows which knobs to turn, and data analysis is validated ahead of time. Reports are displayed on the device or can be automatically uploaded to your local network, so you can check results remotely too. Unbox-and-go REBEL consumable kits make it easy. Reagents are premixed, and each kit comes with electrolyte, diluent, standards, sample plates, and a microfluidic chip. That’s everything you need to run 200 samples. All in one box.