Recombinant Human BMP-6
TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis.
The supplier does not provide quotations for this product through SelectScience. You can search for similar products in our Product Directory.
Great growth factor for our in vitro culture
In vitro culture
We usually purchase our growth factors from Peprotech because the service is excellent, the delivery is fast and the products are great. All growth factors give us great, reliable results, we never had any problem with them. Moreover, their price is very honest.
Review Date: 15 Nov 2021 | PeproTech
As implied by their name, BMPs initiate, promote, and regulate the development, growth, and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling, and maintenance of a variety of other tissues and organs. Increasing evidence indicates that BMP-Smad signaling has a tumor suppressing activity, and that BMPs can inhibit tumor growth. BMP-6 is abnormally expressed in breast cancer cell lines, however, its function in promoting breast cancer development is unknown. The mature and functional form of BMP-6 is a homodimer of two identical 139 amino acid polypeptide chains linked by a single disulfide bond. Each monomer is expressed as the C-terminal part of a precursor polypeptide, which contains a 20 amino acid signal peptide and a 354 amino acid propeptide. This precursor undergoes intracellular dimerization, and upon secretion it is processed by a furin-type protease. Recombinant Human BMP-6 is a 26.2 kDa homodimeric glycoprotein consisting of two 117 amino acid subunits, which correspond to amino acid residues 397 to 513 of the full-length BMP-6 precursor.
Source: HEK293 cells
Synonyms: Bone Morphogenetic Protein-6, VGR, VG-1-related protein
AA Sequence (monomer): VSSASDYNSS ELKTACRKHE LYVSFQDLGW QDWIIAPKGY AANYCDGECS FPLNAHMNAT NHAIVQTLVH LMNPEYVPKP CCAPTKLNAI SVLYFDDNSN VILKKYRNMV VRACGCH
Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.
Biological Activity: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 this effect is 0.03-0.06 μg/ml.
Calculated Molecular Weight: 26.2 kDa
Accession Number: P22004
Gene ID: 654
