Products & ReviewLife Sciences
Reversine
Adenosine receptor, non-muscle myosin II (NM II), MEK1, and aurora kinase inhibitor
Reversine
The supplier does not provide quotations for this product through SelectScience. You can search for similar products in our Product Directory.
Reversine is a 2,6-disubstituted purine derivative that inhibits the human A3 adenosine receptor, nonmuscle myosin II heavy chain, mitogen activated extra-cellular signal regulated kinase-1 (MEK1), and Aurora B kinase (Chen et al.; Perreira et al.; D'Alise et al.).
REPROGRAMMING
- Induces dedifferentiation of lineage-committed mouse myoblasts to multipotent progenitors with osteogenic and adipogenic potential (Chen et al., 2007; Chen et al., 2004).
- Induces dedifferentiation of primary mouse and human dermal fibroblasts to myogenic-competent cells (Anastasia et al.).
- Induces dedifferentiation of annulus fibrosus cells to multipotent mesenchymal progenitors that have the potential to develop along chondrogenic, osteogenic, or adipogenic lineages (Saraiya et al.).
CANCER RESEARCH
- Inhibits cell proliferation and induces polyploidy in the PC-3, HeLa, CWR22Rv1, and DU-145 cancer cell lines (Hsieh et al.).
- Induces differentiation in the human embryonal carcinoma cell line NT2, and in the human promyelocytic leukemia cell line HL60 (D'Alise et al.).
- Blocks proliferation, causes failure of cytokinesis, and induces polyploidy in multiple cancer cell lines (D'Alise et al.).
