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RIME Mass Spectrometry Service
Active Motif25067
Identification of transcriptional co-factors and chromatin associated proteins
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Affinity capture mass spectrometry has traditionally been the approach used to identify and characterize gene regulatory networks associated with a protein of interest.
RIME is superior to traditional affinity capture approaches because this novel cross-linking approach for identification and characterization of interactomes offers the advantages of:
- Targeting only DNA and chromatin associated proteins
- Enabling capture of low affinity interactions that are lost in traditional IP / mass spectrometry
- Permitting more stringent wash conditions to reduce non-specific interactions
- Stabilizing protein-DNA interactions to enable the capture of proteins that are bound at adjacent sites in the DNA and are independent of protein-protein interactions
