Seahorse XF Mito Tox Assay Kit
The kit is designed to use with Agilent Seahorse XF Pro analyzer for easily identifying drug-induced mitochondrial toxicity, to de-risk your drug pipeline. It provides high sensitivity and specificity, reducing false positive and false negatives. It is applicable to screen compound libraries with a throughput of 80 compounds per plate. Assay performance metrics Z’ of > 0.5 is achievable following our assay workflow.
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The Agilent Seahorse XF Mito Tox Assay kit allows for the identification of drug-induced mitochondrial toxicity through direct functional measurements of mitochondrial oxygen consumption rates (OCR). This kit is adapted from the Agilent Seahorse XF Cell Mito Stress Test, the fundamental assay for interrogating mitochondrial function, with improved assay design and data outputs. It provides high sensitivity and specificity along with the toxicity mode of action in one assay, minimizing false positives and false negatives. The XF Mito Tox Assay Kit seamlessly integrates with Agilent Seahorse Pro Controller and Wave Pro software and Agilent Seahorse Analytics in the assay workflow, providing an end-to-end solution for assessing drug-induced mitochondrial toxicity. The software features greatly simplify the entire XF assay experience, from assay design or template creation to data interpretation, facilitating decision making to de-risk drug pipelines.
Each assay kit contains sufficient materials for six full-plate tests in 96-well format. The assay is only compatible with the Agilent Seahorse XF Pro analyzer.
