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Shz-1
Inducer of cardiac differentiation
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Shz-1 is a cell-permeable, sulphonyl hydrazone (Shz) compound that activates cardiac differentiation through induction of genes such as Nkx2.5 (Sadek et al.).
DIFFERENTIATION
- Promotes cardiac differentiation in mouse induced pluripotent stem cells (Quattrocelli et al.).
- Induces cardiac differentiation of human mobilized peripheral blood mononuclear cells; these cells enhance myocardial regenerative repair when injected in a cryo-injured rat heart model (Sadek et al.).