Products & ReviewLife Sciences
Sinefungin
Epigenetic modifier; Inhibits DNA methyltransferases (DNMTs)
Sinefungin
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Sinefungin is a DNA methyltransferase (DNMT) inhibitor (IC₅₀ = 0.1 - 20 μM; Copeland et al.) and an analog of the methyl donor S-adenosyl-L-methionine (SAM; Nolan; Horiuchi et al.).
IMMUNOLOGY
- Antiparasitic activity against malarial, trypanosomal, and leishmanial species (Nolan; Trager et al.; Dube et al.).
- Inhibits Newcastle disease and vaccinia virus multiplication (Pugh et al.).
- Inhibits pneumococcal biofilm growth in vitro and colonization in an in vivo rat model (Yadav et al.).
