Single SOMAmer Reagents (SSRs)
Single SOMAmer™ Reagents (SSRs) are synthetic, animal-free affinity reagents for protein detection workflows such as ELISAs and pull-down assays. With high specificity, thermal stability and batch-to-batch reproducibility, SSRs overcome common antibody limitations. Their small size improves epitope access, and with nearly 11,000 off-the-shelf reagents available, they enable faster, more reliable research.
SSRs bind to a protein’s 3D structure
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Single SOMAmer Reagents (SSRs) are synthetic affinity reagents designed for protein detection workflows. They function in confirmatory proteomic applications such as pull-down assays. Engineered for high specificity and slow off-rates, SSRs overcome many common antibody limitations including poor batch-to-batch reproducibility, instability and high production variability. Produced entirely through chemical synthesis, SSRs are thermally stable, reproducible and animal-free – aligning with modern ethical and regulatory standards.
Their small size (8–20 kDa versus ~150 kDa for antibodies) enables better access to epitopes and reduces nonspecific binding, making them ideal for low-abundance or structurally challenging protein targets. With nearly 11,000 unique off-the-shelf reagents available – representing half the human proteome – SSRs offer a scalable, ready-to-use solution for accelerating research in both academic and translational settings.
Key Features & Benefits
- Easy integration: SSRs fit into pull-down workflows for ELISA and mass spectrometry
- An extensive selection: Access nearly 11,000 reagents for detecting proteins, including rare and low-abundance proteins (e.g., IL-6)
- Reduced off-target effects: Specialty-engineered aptamers reduce cross-reactivity commonly seen with antibodies
- Exceptional reliability: SSRs offer a one-year shelf life and withstand freeze-thaw cycles for lasting performance
Relevant Applications
- Mass Spectrometry
- Enzyme-linked Immunosorbent Assays (ELISAs)
