SiriusT3 Automated platform for the determination of Physicochemical Properties

The Sirius T3 is ideal for early-stage compound screening, PhysChem characterization, and pre-formulation studies, running complicated assays with automated reagent delivery, stirring, spectra collection, pH measurement, and temperature control.

Benefits:

• Elucidate drug potential
• Globally renowned as the gold standard technique for determination of pKa, logP/D and solubility of ionizable compounds.
• Rich insights to discovery scientists allowing them to make accurate and assured decisions about their drug candidates.
• Determine pKa values using two techniques: spectrometric (for UV-active compounds) and potentiometric (for non-UV active compounds). With high throughput automated screening capabilities, SiriusT3 can complete up to 80 assays a day.
• Determine the intrinsic solubility of the different forms (crystalline and amorphous) for polymorphs compounds using the Pion’s CheqSol technique.

Features:

• Requiring only sub-milligram sample quantities in most cases, the SiriusT3 can complete the analysis in less than 6 minutes per titration using the high throughput pKa screening.
• Determine pKa values using two techniques: spectrometric (for UV-active compounds) and potentiometric (for non-UV active compounds). With high throughput automated screening capabilities, SiriusT3 can complete up to 80 assays a day.‍
• Measure log P/D as a function of pH in less than 2 hours using the potentiometric technique in place of traditional shake-flask methods. Determine kinetic and intrinsic solubility using Pion’s patented CheqSol technique within two hours.
• Use the CheqSol technique to provide intrinsic solubility as a function of pH and generate detailed information about the extent and duration of the supersaturated states.