SONICC®
Remove the guesswork. SONICC ® finds protein crystals that other technologies cannot. The ultimate imaging technology in visualizing protein crystals, Second Order Nonlinear Imaging of Chiral Crystals (SONICC) definitively finds crystals buried in precipitate or submicron crystals naked to the eye.
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Great instrument for crystal detection
Protein and APIs crystallinity detection
The signal to noise ratio is very high for this second harmonic generation microscopy. And the use of this system is straight forward. But the beampath needs to be realigned sometimes.
Review Date: 9 Mar 2017 | FORMULATRIX®, Inc.
SONICC® provides users the ability to:
- Find Hidden Crystals
Even Those Not Visible by The Eye - Discover crystals buried in precipitate or crystals not visible by the naked eye.
- Detect Sub-Micron Crystals to Not Miss Hits
Detect thin crystals, microcrystals <1 μm, and crystals obscured in birefringent LCP.
- Target the Right Crystals
Distinguish Between Protein or Salt - Know if your detected crystals are protein or not using integrated UV imaging.
- Find Models that Fit Your Lab’s Throughput
SONICC comes in two configurations to better fit your lab's needs:- A benchtop model for imaging a single plate at a time. Best for lab's where throughput is not a concern.
- An integrated model that is built into a ROCK IMAGER 1000 which allows you to store and automatically image up to 940 plates.
Two powerful technologies, Second Harmonic Generation (SHG) and Ultraviolet Two-Photon Excited Fluorescence (UV-TPEF) are combined in a completely automated imager to quickly image your high throughput crystallization plates and positively identify protein crystals. Crystals appear white against a stark black background, helping you to identify crystals even in murky environments. SONICC can detect extremely thin crystals, microcrystals <1 μm, and crystals obscured in birefringent LCP.
Major pharmaceutical and academic research labs worldwide find SONICC to be extremely successful, cost-effective, and efficient.
