Products & ReviewLife Sciences
STAT5 Inhibitor
JAK/STAT pathway inhibitor; Inhibits STAT5
STAT5 Inhibitor
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STAT5 Inhibitor is a cell-permeable, nonpetidic nicotinoyl hydrazone that specifically suppresses STAT5 (IC₅₀ = 47 µM) via binding to its SH2 domain. It shows reduced potency towards the SH2 domains of STAT1, STAT3, or LCK (Mí¼ller et al.).
IMMUNOLOGY
- Induces partial apoptosis of mature eosinophils at high concentrations (Schwartz et al.).
- Rescues IL-17 production in a proportion of restimulated TH17 clones (Zielinski et al.)
- Reduces growth of induced regulatory T cells (iTregs) in vitro (Betts et al.).
