STO-609
Calcium signaling inhibitor; Inhibits calcium/calmodulin-dependent kinase kinases (CaMKKs)
STO-609 (Acetate)
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STO-609 is a cell-permeable, selective inhibitor of ATP-competitive calcium/calmodulin-dependent kinase kinases (CaMKK). STO-609 inhibits the activities of recombinant isoforms CaMKKα (Ki = 80 ng/mL) and CaMKKβ (Ki = 15 ng/mL) and also inhibits their autophosphorylation (Kukimoto-Niino et al.; Tokumitsu et al.). STO-609 reduces thrombin-induced nuclear localization of NF-κB activation in endothelial cells (Bair et al.). This product is supplied as the acetate salt form of the molecule.
DIFFERENTIATION
- Stimulates osteoblast formation and inhibits osteoclast differentiation in mouse mesenchymal stem cells, and reverses age-associated decline in bone mass (Cary et al.; Pritchard et al.).
CANCER RESEARCH
- Decreases in vitro growth of human hepatic cancer cell lines, and decreases tumor burden in mouse hepatic tumor model (Lin et al.).
