Suramin
Tryosine kinase inhibitor and epigenetic modifier; Inhibits PDGF, FGF, EGF, TGFß, SIRT1, and SIRT5
Suramin (Sodium Salt)
The supplier does not provide quotations for this product through SelectScience. You can search for similar products in our Product Directory.
Suramin is a bis-polysulfonated naphthylurea that can bind to and inhibit PDGF, FGF, EGF, TGF-β, SIRT1, and SIRT5 (Stein). Suramin also blocks G protein binding to G protein-coupled receptors (GPCRs), inhibits the binding of calmodulin to recognition sites on the ryanodine receptor-1 (IC₅₀ = 4.9 μM), and non-selectively antagonizes P2X and P2Y purinergic receptors (10 - 100·μM; Klinger et .; Charlton et al.). This product is supplied as the sodium salt of the molecule.
DISEASE MODELING
- Attenuates fibrosis in limb muscles in mouse model of Duchenne's muscular dystrophy (Taniguti et al.).
CANCER RESEARCH
- Inhibits angiogenesis and growth of various tumors and human cancer cell lines (McGreary et al.; Zaniboni; Stein).
IMMUNOLOGY
- Competitive inhibitor of reverse transcriptase and protects T lymphocytes against human immunodeficiency virus (HIV) infection in vitro (Carteau et al).
- Kills human African trypanosomiasis parasites, potentially through preferential binding to parasite glycolytic enzymes (Fairlamb & Bowman; Barrett et al.).
