Therapeutic Antibody Evaluation Services
The JAX Therapeutic Antibody Evaluation Services rely on a unique humanized mouse collection. Using its humanized FcRn models to deliver accurate data and get therapeutic candidates into the clinic—and ultimately in the hands of physicians and patients—faster.
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From preclinical to clinical: get relevant translational and fast half-life comparison data
The Jackson Laboratory evaluates the in vivo stability of therapeutic antibodies and other Fc-based biologics using its unique platform consisting of humanized mouse models that are deficient in murine FcRn and express human FcRn at different levels. Developed by JAX professor Derry Roopenian, Ph.D., these mice allow for:
- Generation of faster, predicative clinically-relevant data for antibody stability
- Effective and proven alternative to non-human primates,
- Preclinical pharmacokinetic (PK) analysis of Fc-domain based therapeutic candidates
- Cost effectiveness, since they require only small quantities of a given molecule
- Testing of any kind of Fc-domain albumin-conjugate, or therapeutic carried by albumin used in immuno-oncology and autoimmune research, among others
The humanized mouse platform: Description of the most used models
- B6.Cg-Fcgrttm1Dcr Tg(FCGRT)32Dcr/DcrJ (014565) mice have a null mutation for the mouse gene and a transgene expressing the human FcRn under the endogenous promoter (hTg32). These mice have the highest, most human-like protection of humanized IgG and are the best model for use when maximum half-life data is required
- B6.Cg-Fcgrttm1Dcr Tg(CAG-FCGRT)276Dcr/DcrJ (004919) mice carry a null mutation for the mouse gene and a transgene expressing human FcRn. Mice hemizygous for the human FcRn transgene (hTg276) are best suited to detect subtle differences in antibody persistence in vivo
- B6.Cg-Fcgrttm1Dcr Prkdcscid Tg(FCGRT)32Dcr/DcrJ (018441) mice express the hTg32 transgene and are immunodeficient. These mice have the highest, most human-like protection of humanized IgG and are useful in evaluating Fc-domain based therapeutics that are potentially immunogenic or involve xenografts
- B6.Cg-Albem12Mvw Fcgrttm1Dcr Tg(FCGRT)32Dcr/MvwJ (025201) albumin knockout hTg32 mice are an effective, human-like model for characterization of the pharmacokinetics of albumin-conjugates, or therapeutics carried by albumin
