Thermo Scientific™ MAbPac™ HIC-10 Monoclonal Antibody Column
Designed for separation of monoclonal antibodies (MAbs) and related biologics by hydrophobic interaction, the Thermo Scientific™ MAbPac™ HIC-10 LC column is a high resolution silica column. The MabPac HIC-10 column's unique chemistry provides high resolution, excellent biocompatibility, and selectivity that is different from other HIC columns on the market. The MAbPac HIC-10 column is based on high-purity, spherical, wide-pore…
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Analysis
Column resolution is excellent. After conditioning with 0.5%TFA, the column can be used without TFA in the mobile phase thus improving MS ionization. Use a shallow gradient ranging from 20 to 40% organic over a wide run time 30min to achieve the ideal separation of mAb fragments.
Review Date: 11 Feb 2022 | Thermo Fisher Scientific
Designed for separation of monoclonal antibodies (MAbs) and related biologics by hydrophobic interaction, the Thermo Scientific™ MAbPac™ HIC-10 LC column is a high resolution silica column. The MabPac HIC-10 column's unique chemistry provides high resolution, excellent biocompatibility, and selectivity that is different from other HIC columns on the market.
The MAbPac HIC-10 column is based on high-purity, spherical, wide-pore (1,000Å), 5μm silica particles functionalized with proprietary alkyl amide groups. Its advanced surface bonding technology leads to excellent chemical stability, high efficiency, and unique selectivity optimized for MAbs and different from other HIC phases.
Features:
- Excellent biocompatibility and extremely low carryover
- High resolution and high efficiency
- Compatible with both organic solvent and aqueous mobile phases
- Rugged column stability
Column Details:
- Type: Hydrophobic Interaction, Alkyl amide
- Particle Size: 5 µm
- Pore Size: 1000 Å
- Length: 100, 250 mm
- ID: 4.6 mm
