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Tranylcypromine
Epigenetic modifier; Inhibits lysine-specific demethylase 1 (LSD1)
Tranylcypromine (Hydrochloride)
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Tranylcypromine is an epigenetic modifier that is an irreversible inhibitor of Lysine-Specific Demethylase 1 (LSD1, IC₅₀ = 20.7 µM). The catalytic site of LSD1 shares similarity with monoamine oxidase (MAO) enzymes and Tranylcypromine also inhibits MAO A (IC₅₀ = 2.3 µM) and MAO B (IC₅₀ = 0.95 µM). (Lee et al., Schmidt and McCafferty)
REPROGRAMMING
- Enables chemical reprogramming (without genetic factors) of mouse embryonic fibroblasts to induced pluripotent stem (iPS) cells, in combination with CHIR99021, Forskolin, Valproic Acid, 3-Deazaneplanocin A, and E-616452 (Hou et al.).
- Promotes reprogramming of human keratinocytes to iPS cells using only 2 factors (OCT4 and KLF4), in combination with CHIR99021 (Li et al.).
- Converts mouse epiblast-like stem cells to a more primitive embryonic stem (ES)-like state, in combination with several other small molecules (Zhou et al.).
MAINTENANCE AND SELF-RENEWAL
- Inhibits proliferation of mouse neural stem cells (Sun et al.).
- Blocks differentiation of mouse ES cells as well as the differentiation-induced demethylation of ES-specific enhancers (Whyte et al.).
