TSKgel SW Series Gel Filtration Columns for Biomolecules
TSKgel SW-type columns for size exclusion/gel filtration analysis of antibodies and other proteins are silica-based. A hydrophilic diol-type bonded phase shields the silica surface from interacting with protein samples.
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Good quality, improvable batch to batch reproducibility.
High & low molecular weight heparin
The columns are easy to use but take care when doing so. Loss of resolution on the low molecular weight region (column bench 3000 + 2000) occurs very quickly, especially in mobile phase sodium phosphate. Ammonium acetate buffered at pH 6 so they are more stable. It seems like some particular stationary phase batches are more stable and reproducible than others. These columns have never been cheap.
Review Date: 7 Feb 2020 | Tosoh Bioscience
TSKgel SW-type columns for size exclusion/gel filtration analysis of antibodies and other proteins are silica-based. A hydrophilic diol-type bonded phase shields the silica surface from interacting with protein samples.
TSKgel SW-type columns contain more pore volume per unit column volume, which results in higher MW selectivity or better resolution. In addition, they show low adsorption and well-defined pore size distribution, which are requirements for high performance GFC of proteins.
Various pore sizes are available in TSKgel SW, SWXL, SuperSW, UltraSW and UP-SW product lines.
- TSKgel G3000SWXL is the working horse of the biopharmaceutical industry for aggregate analysis of therapeutic antibodies in QC.
- TSKgel UP-SW columns are optimized for use with UHPLC systems and allow a smooth transfer of standard methods from SWXL based HPLC analysis to UHPLC.
- TSKgel SuperSW mAb columns are optimized for antibody separation.
- TSKgel UltraSW Aggregate feature smaller particles and are optimized for analysis of higher aggregates.
