Products & ReviewLife Sciences
UM729
Pyrimido-indole derivative that enhances HSC self-renewal in vitro
UM729
The supplier does not provide quotations for this product through SelectScience. You can search for similar products in our Product Directory.
UM729 is a pyrimido-[4,5-b]-indole derivative which enhances the self-renewal of human hematopoietic stem cells in vitro. UM729 does not inhibit the aryl hydrocarbon receptor (AHR) pathway, but has been shown to collaborate with AHR antagonists in preventing differentiation of acute myeloid leukemia (AML) cells in culture.
MAINTENANCE AND SELF-RENEWAL
- Enhances human hematopoietic stem cell self-renewal in vitro (Fares et al.).
CANCER RESEARCH:
- Collaborates with StemRegenin 1 (SR1) in preventing differentiation of AML cells in culture (Pabst et al.).
