XSelect HSS and CSH XP Columns
UHPLC columns for unmatched selectivity choice

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Robust product, with high capacity of use.
Chemical intermediate
Robust product, with high capacity of use. Added value for complex matrix analysis.
Review Date: 18 Oct 2018 | Waters
Great, reliable product.
Reaction Monitoring
The columns give us great separation and, with our daily and weekly maintenance, they can last up to a year. In a standard year, we do thousands of injections.
Review Date: 15 Oct 2018 | Waters
These columns are the best for the quality of my results
Pharmaceutical Technology
These columns are easy to use and to clean. They were the best chance for my samples.
Review Date: 11 Oct 2018 | Waters
Very happy with the results obtained
Environmental analysis
Your products have an unbeatable quality.
Review Date: 9 Oct 2018 | Waters
Great resolution and short retention times
Pharmaceutical products QC analysis
The column is good for what we were using it for. Short retention times with a nice resolution. Good for routine analysis and development.
Review Date: 9 Oct 2018 | Waters
Good product, can use for UPLC and HPLC
Analyze peptides
After thousand injection, the column isn't very good.
Review Date: 8 Oct 2018 | Waters
A bit stressed when using these columns.
Impurities in pharmaceutical compounds (API or intermediates)
We have had some problems with these columns. Some new one have to be flushed for several hours to have proper results.
Review Date: 8 Oct 2018 | Waters
Long life-time!
Serotonin metabolite in serum samples
The columns are stable and robust with very long life-time, our experience over 6000 runs, provides good value for money.
Review Date: 8 Oct 2018 | Waters
Great column, same results as smaller particle size
Chemical small molecule analysis
Great separation, with low back pressure at high flow rates on UPLCMS
Review Date: 6 Oct 2018 | Waters
Excellent and very easy to use
I use these columns for HPLC and LCMS
XSelect columns performance are great and worked very well where other columns are failed
Review Date: 5 Oct 2018 | Waters
XSelect eXtended Perfomance (XP) Columns provide the most diverse selection of sorbents for ultra-high performance (UHPLC) separations. The HSS (High-Strength Silica) and CSH (Charged-Surface Hybrid) base particles provide separation scientists with uniquely selective columns that deliver operational stability and method scalability for UPLC, UHPLC and HPLC separation platforms.
Diverse Retention Characteristics
Method development scientists use selectivity and retentivity to influence chromatographic behavior. The selection of phases in the XSelect family offers the ability to achieve selectivity and retention of a wide variety of compounds without compromising performance attributes such as superior peak shape for basic compounds, low column bleed, excellent batch-to-batch reproducibility or high efficiency.
Maximum Column Performance
When used on low dispersion UHPLC instrumentation, XSelect eXtended Perfomance (XP) columns improve system performance by decreasing peak width and increasing peak height with the result of maximizing analyte sensitivity. All XSelect HSS and XSelect CSH XP columns are designed to be stable at high operational backpressures to allow faster flow rates to accelerate sample throughput.
VanGuard Column Protection
The often complex sample matrices encountered in pharmaceutical, natural product, environmental, and industrial chemical analysis prematurely shorten analytical column lifetime and degrade chromatographic performance. Waters VanGuard Cartridge Columns help improve analytical column performance by removing particulate and chemical contamination that may be present in the mobile-phase stream—without compromising chromatographic performance.