MACSima™ Platform from Miltenyi Biotec

The MACSima™ Platform, a revolutionary multiomics solution, streamlines your spatial biology research from end to end, reducing experimental workload and generating impactful data in no time. The platform's core, the fully automated MACSima System, combines high-plex spatial protein profiling with RNA detection on the same section, pushing the boundaries of what’s possible. The MACSima Platform empowers researchers to make pioneering discoveries by facilitating the identification of novel cell types, understanding their interactions, and exploring their impact on the tissue microenvironment, thereby advancing biomarker identification, drug discovery, and the development of precision immunotherapy.

• Same-section multiomics– Gain a deeper understanding of the causes and consequences of biological events by connecting phenotype with gene expression. Analyze hundreds of protein markers and dozens of RNAs within a single tissue section. The MACSima Platform is the first on the market to achieve this comprehensive capability.
• High-plex spatial profiling of proteinsand RNA – Use MICS (MACSima Imaging Cyclic Staining) technology to analyze hundreds of protein markers and dozens of RNAs within a single sample in one run. Whether you choose a compact panel of 15-20 protein markers or delve into extensive panels encompassing up to 200+ protein markers and 27 RNAs, the possibilities are vast.
• Comprehensive spatial biology platform– Count on the MACSima Platform for a complete and harmonized solution, featuring instrument, sample carriers, antibodies pretested for MICS technology, and analysis software. Miltenyi Biotec stands out as the sole provider offering this all-embracing package.
• Antibodies for highest convenience, flexibility, and reproducibility– Take advantage of the world's largest ultra-high-plex antibody portfolio for spatial biology, targeting 600+ biomarkers. Enjoy complete flexibility by choosing individual antibodies or ready-to-use 96-well plates with antibody panels. With REAscreen™ Design, you can even have personalized panels for the highest standardization, whether you require a large stock of a 30-marker panel or just a few replicates of a 100-marker panel.
• RNAsky™ Detection Probes for spatial transcriptomics – Explore RNAs alongside proteins on the same section. Offered in predefined or customizable panels, these probes unlock new targets undetectable by antibodies, like cytokines.
• Automated processing and imaging – Plan your experiment and leave the execution to the MACSima System.
• Analyze any kind of fixed sample – Image all types of fixed samples, whether tissue or single cells, and perform any analysis you can imagine.
• Intuitive analysis – Unlock the full potential of your spatial data with the MACS^® iQ View Analysis Software. Its intuitive design makes analyzing vast spatial biology experiment data accessible to users of all backgrounds, enabling quick generation of conclusive and publication-ready results. It features an intuitive user interface and offers many analysis options (t-SNE/UMAP plots, heatmaps, distance mapping, …).
• Technical support and trusted scientific partnership – Receive comprehensive support from a team of field application specialists, spanning the entire spectrum – from panel design and experimental setup to data analysis. Miltenyi Biotec uses the MACSima Platform in its own research initiatives, demonstrating a profound understanding of scientists' needs and fostering partnerships on eye level.